PUBLICATIONS

2023

Gopalakrishnan, J., Feistel, K., Friedrich, B.M., Grapin-Botton, A., Jurisch-Yaksi, N., Mass, E., Mick, D.U., Müller, R.-U., May-Simera, H., Schermer, B., Schmidts, M., Walentek. P., Wachten, D. (2023)

Emerging principles of primary cilia dynamics in controlling tissue organization and function 

EMBO J, e113891, doi: 10.15252/emboj.2023113891

Shinde, S.R., Mick, D.U., Aoki, E., Rodrigues, R.B., Gygi, S.P., Nachury, M.V. (2023)

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia. 

Dev Cell, 677-693.e9, doi: 10.1016/j.devcel.2023.03.003

2022

Hansen, J.N., Kaiser, F., Leyendecker, P., Stüven, B., Krause, J.H., Derakhshandeh G., S.F., Jaazba, I., Sroka, T.J., Preval, K.M., Desai, P.B., Kraut, M., Theis, H., Drews, A.D., De-Domenica, E., Händler, K., Pazour, G.J., Mick, D.U., Wachten, D. (2022) 

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.

EMBO Rep., 13:e54315, doi: 10.15252/embr.202154315

2021

Wachten, D., Mick, D.U. (2021)

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling.

Pharmacol. Ther., 224:107836, doi: 10.1016/j.pharmthera.2021.107836.


May, E.A., Kalocsay, M., Galtier D'Auriac I., Schuster P.S., Gygi SP, Nachury M.V., Mick, D.U. (2021) 

Time-resolved proteomics profiling of the ciliary Hedgehog response.

J. Cell. Biol. 220, e202007207, doi: 10.1083/jcb.202007207


May, E.A., Sroka, T.J., Mick, D.U. (2021)

Phosphorylation and ubiquitylation regulate protein trafficking, signaling, and the biogenesis of primary cilia.

Front. Cell. Dev. Biol. 9, 664279, doi: 10.3389/fcell.2021.664279

2020

Hansen, J-N., Kaiser, F., Klausen, C., Stüven, B., Chong, R., Bönigk, W., Mick, D.U., Möglich, A., Jurisch-Yaksi, N.,  Schmidt, F.I., Wachten, D. (2020)

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.

Elife 9:e57907, doi: 10.7554/eLife.57907

2019

Mick, D.U. (2019)

Establishing cell culture-based experimental setups for proximity labeling using ascorbate peroxidase (APEX).

Methods Mol. Biol. 2008, 29-39. doi: 10.1007/978-1-4939-9537-0_3


Nachury, M.V. and Mick, D.U. (2019)

Establishing and regulating the composition of cilia for signal transduction.

Nat. Rev. Mol. Cell Biol. 20, 389-405. doi: 10.1038/s41580-019-0116-4

2016

Bareth, B., Nikolov, M., Lorenzi, I., Hildenbeutel, M., Mick, D. U., Helbig, C., Urlaub, H., Ott, M., Rehling, P. and Dennerlein, S. (2016)

Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1.

Mol. Cell. Biol. 27, 1570-1580. doi: 10.1091/mbc.E15-12-0811 

2015

Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gygi, S. P., and Nachury, M. V. (2015)

Proteomics of Primary Cilia by Proximity Labeling.

Dev. Cell 35, 497-512. doi: 10.1016/j.devcel.2015.10.015 

Commented by Nikonova, A. S. and Golemis, E. A. in the same issue

2013

Bareth, B., Dennerlein, S., Mick, D. U., Nikolov, M., Urlaub, H. and Rehling, P. (2013)

The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.

Mol. Cell. Biol., 33, 4128-4137. doi: 10.1128/MCB.00747-13 

2012

Mick, D. U.*, Dennerlein, S.*, Wiese, H., Reinhold, R., Pacheu-Grau, D., Lorenzi, I., Sasarman, F., Weraarpachai, W., Shoubridge, E. A., Warscheid, B. and Rehling, P. (2012)

MITRAC links mitochondrial protein translocation to respiratory chain assembly and translational regulation.

Cell 151, 1528-1541. doi: 10.1016/j.cell.2012.11.053

*authors contributed equally to this work

2011

Reinhold, R., Bareth, B., Balleininger, M., Wissel, M., Rehling, P. and Mick, D. U. (2011)

Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast.

Hum. Mol. Genet. 20, 2379-2393. doi: 10.1093/hmg/ddr145

 

Lupo, D., Vollmer, C., Deckers, M., Mick, D. U., Tews, I., Sinning, I. and Rehling, P. (2011)

Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.

Traffic 12, 1457-1466. doi: 10.1111/j.1600-0854.2011.01239.x 


Mick, D. U., Fox, T. D. and Rehling, P. (2011)

Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation.

Nat. Rev. Mol. Cell Biol. 12, 14-20. doi: 10.1038/nrm3029

2010

Mick, D. U., Vukotic, M., Piechura, H., Meyer, H. E., Warscheid, B., Deckers, M. and Rehling, P. (2010)

Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria.

J. Cell Biol. 191, 141-154. doi: 10.1083/jcb.201007026

 

Chacinska, A., van der Laan, M., Mehnert, C. S., Guiard, B., Mick, D. U., Hutu, D. P., Truscott, K. N., Wiedemann, N., Meisinger, C., Pfanner, N., and Rehling, P. (2010)

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Mol. Cell. Biol. 30, 307-318. doi: 10.1128/MCB.00749-09


Bauerschmitt, H.*, Mick, D. U.*, Deckers, M., Vollmer C., Funes S., Kehrein K., Ott M., Rehling P. and Herrmann, J. M. (2010)

Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.

Mol. Cell. Biol. 21, 1937-1944. doi: 10.1091/mbc.e10-02-0101

*authors contributed equally to this work

2009

Wagner, K., Mick, D. U., and Rehling, P. (2009)

Protein transport machineries for precursor translocation across the inner mitochondrial membrane.

Biochim. Biophys. Acta 1793, 52-59. doi: 10.1016/j.bbamcr.2008.05.026

2007

Mick, D. U., Wagner, K., van der Laan, M., Frazier, A. E., Perschil, I., Pawlas, M., Meyer, H. E., Warscheid, B., and Rehling, P. (2007)

Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.

EMBO J. 26, 4347-4358. doi: 10.1038/sj.emboj.7601862

2006

Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D. U., Hutu, D. P., Voos, W., Truscott, K. N., Chacinska, A., Pfanner, N., Rehling, P. (2006)

Tim50 maintains the permeability barrier of the mitochondrial inner membrane.

Science 312, 1523-1526. doi: 10.1126/science.1127628 


Frazier, A. E., Taylor, R. D., Mick, D. U., Warscheid, B., Stoepel, N., Meyer, H. E., Ryan, M. T., Guiard, B., and Rehling, P. (2006)

Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.

J. Cell Biol. 172, 553-564. doi: 10.1083/jcb.200505060 


Van der Laan, M., Wiedemann, N., Mick, D. U., Guiard, B., Rehling, P, Pfanner, N. (2006)

A role for Tim21 in membrane potential-dependent preprotein sorting in mitochondria.

Curr. Biol. 16, 2271-2276. doi: 10.1016/j.cub.2006.10.025

2005

Brandner, K., Mick, D. U., Frazier, A.E., Taylor, R. D., Meisinger, C., and Rehling, P. (2005)

Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome.

Mol. Biol. Cell 16, 5202-5214. doi: 10.1091/mbc.e05-03-0256

Photo: 

"Das Hörsaalgebäude auf dem Campus Homburg"

Universität des Saarlandes

© Felix Meyer